PReS-FINAL-2185: Prognostic markers in juvenile vs. adult-onset ankylosing spondylitis
نویسندگان
چکیده
Methods 143 JoAS were compared with 413 AoAS patients attending a secondary care rheumatology hospital. A diagnosis of AS was made using the 1987 modified New York criteria. The following clinical parameters were recorded: sex; age at symptom onset (JoAS only); age at Rheumatologist-made diagnosis; the most recent BASFI, BASDAI, BASMI; HLA-B27 genotype status; the occurrence at any time point of psoriasis, uveitis, enthesitis, inflammatory bowel disease (IBD) or AS-related surgery (hip, shoulder or spinal). Two group comparisons were made with continuitycorrected Chi-squared, unpaired Student’s t-tests and non-parametric Mann-Whitney U-tests. Logistic regression was used to adjust for time since diagnosis.
منابع مشابه
PReS-FINAL-2168: Comparison of safety and retention rate of TNF antagonist therapy in juvenile-onset and adult-onset ankylosing spondylitis: data from the spanish registry biobadaser 2.0
Introduction Ankylosing spondylitis (AS) is a chronic inflammatory disease that belongs to the group of spondyloarthritis, which involves the spine, peripheral joints and entheses. Juvenile-onset AS affects children under the age of 16 years and present a clinical course different from adultonset AS. Several randomized clinical trials have shown that TNF antagonists are an effective alternative...
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Introduction Juvenile spondyloarthritis (J-spa) is characterized by a predominantly peripheral involvement and more frequent presentation as undifferentiated forms. However, like its adult-onset equivalent, it has the potential to develop structural damage and evolve to juvenile ankylosing spondylitis (J-AS), with consequent functional impairment that will last for the lifetime of the patient. ...
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Introduction Enthesitis related arthritis (ERA) is a chronic inflammatory disorder primarily affecting the axial skeleton as well as peripheral joints and entheses. DMARD’s are succesful in controling peripheral disease; however their effectiveness is diminished when axial inflammation is present. The use of anti tnfa medications in adult patients with ankylosing spondylitis is well documented....
متن کاملComparison in clinical features and life impact between juvenile-onset and adult-onset ankylosing spondylitis.
BACKGROUND/AIM To compare the differences in clinical characteristics and disease impact on life between patients with juvenile-onset ankylosing spondylitis (JoAS) and patients with adult-onset AS (AoAS). MATERIALS AND METHODS Demographic and clinical data were collected from 139 AS patients. Disease activity was defined with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Fu...
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